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April 15, 2026AgingOpen Access

Cross species activity of TERT human telomerase component

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Authors

SRSánchez-Vázquez RaúlMPMartínez Sirés PaulaASArpita Saha

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Overview

Cross-species analysis demonstrates human TERT's viability in select mammalian models, indicating therapeutic potential.

Key Points

  • Investigate the functionality of human TERT with telomerase RNA from various mammalian species.
  • Introduced human TERT into primary lung fibroblasts from several species.
  • Assessed the generation of telomeric repeats in cell extracts.
  • Analyzed telomere length during extended cell culture.
  • Human TERT formed an active complex with telomerase RNA from monkey, pig, rabbit, and rat.
  • No activity observed with telomerase RNA from dog or mouse.
  • Only monkey and human cells showed progressive telomere lengthening during long-term culture.

Cite This Study

Raúl et al. (2026) studied this question.

synapsesocial.com/papers/69df2b85e4eeef8a2a6b0782https://doi.org/10.18632/aging.206372
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Telomeres control human telomerase (TERT) expression through non-telomeric TRF22025
  2. 2Construction of TERT Monoallelic Knockout and TERT Overexpression of Porcine Cell Lines and Study of the Cellular Biological Characteristics2026
  3. 3Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle.2026
  4. 4Telomeres control human telomerase (hTERT) expression through non-telomeric TRF22025
  5. 5Pan-cancer experimental characteristic of human transcriptional patterns connected with telomerase reverse transcriptase (TERT) gene expression status2024 · 3 citations