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April 15, 2026Nature CommunicationsOpen Access

Dormancy regulon reduction was pivotal to the evolution of Mycobacterium tuberculosis

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Authors

MSMatthew SilcocksJLJames P. LingfordCCChen‐Yi Cheung

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Overview

Phenotypic screening identifies adaptive gene changes in Mycobacterium tuberculosis, suggesting evolutionary mechanisms.

Key Points

  • The research aims to explore how gene and regulatory changes contribute to the evolution of Mycobacterium tuberculosis, particularly focusing on dormancy.
  • Conducted phenotypic selection screenings on 2506 Mycobacterium tuberculosis isolates from Vietnam.
  • Analyzed lineage-specific gene mutations, particularly focusing on the dormancy gene Rv0080.
  • Extended screening to the broader Mycobacterium tuberculosis complex phylogeny.
  • Identified Rv0080 as a key target of selection with a high mutation rate in certain lineages.
  • Observed a selection rate (dN/dS=9.37) for Rv0080 exceeding other genes.
  • Demonstrated survival advantages in hypoxic conditions linked to modifications in Rv0080.

Cite This Study

Silcocks et al. (2026) studied this question.

synapsesocial.com/papers/69df2ba0e4eeef8a2a6b0a32https://doi.org/10.1038/s41467-026-71566-x
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