Why the study?
Does N2 peptide or 21G6 F(ab')(2) reduce cardiac I/R injury in a murine model of acute myocardial infarction?
Does N2 peptide or 21G6 F(ab')(2) reduce cardiac I/R injury in a murine model of acute myocardial infarction?
Blockade of self-reactive IgM using N2 peptide or 21G6 F(ab')(2) significantly reduces cardiac ischemia/reperfusion injury in a murine model.
Caution against clinical translation; extends preclinical evidence for IgM blockade in ischemia/reperfusion injury.
The findings in this study identify potential therapeutics [i.e. N2 peptide or 21G6 F(ab')(2)] that prevent specific IgM binding to ischaemic antigens in the heart, resulting in a significant reduction in cardiac I/R injury.
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Haas et al. (2010) studied this question.
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