November 4, 2003Circulation

Inhibition of δ-Protein Kinase C Protects Against Reperfusion Injury of the Ischemic Heart In Vivo

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Why the study?

Does intracoronary application of a selective deltaPKC inhibitor reduce reperfusion injury in preclinical models of acute myocardial infarction?

Population

In vivo porcine model of acute myocardial infarction (AMI) and isolated perfused mouse hearts

Design

Preclinical

Authors

KIKoichi InagakiKyoto University LCLeon ChenThe University of Sydney FIFumiaki IkenoStanford Medicine

Discussion

Member takes

Implication

Warrants clinical trials of deltaPKC inhibition in AMI reperfusion; leaves open translation of animal benefits to patients.

Structured PICO

Does intracoronary application of a selective deltaPKC inhibitor reduce reperfusion injury in preclinical models of acute myocardial infarction?

Population

In vivo porcine model of acute myocardial infarction (AMI) and isolated perfused mouse hearts

Intervention

Intracoronary application of a selective deltaPKC inhibitor at the time of reperfusion

Outcome

Infarct size, cardiac function, troponin T release, apoptosis, and ATP level recoverysurrogate

Inhibition of deltaPKC at the time of reperfusion protects against ischemia/reperfusion injury in preclinical models of acute myocardial infarction.

Cite This Study

Inagaki et al. (2003) studied this question.

synapsesocial.com/papers/6a70f19ef44fa9f079deb12b https://doi.org/10.1161/01.cir.0000101682.24138.36

Topics

Bremelanotide Women and heart disease

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Inhibition of δ-Protein Kinase C Protects Against Reperfusion Injury of the Ischemic Heart In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Inhibition of δ-Protein Kinase C Protects Against Reperfusion Injury of the Ischemic Heart In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider