Why the study?
Does TG100-115 reduce infarct development and preserve myocardial function in animal models of myocardial ischemia/reperfusion injury?
Population
Animal models of myocardial infarction (ischemia/reperfusion injury)
Design
Preclinical
Authors
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Supports exploration of delayed PI3K gamma/delta inhibition; leaves open translation to human reperfusion injury.
Does TG100-115 reduce infarct development and preserve myocardial function in animal models of myocardial ischemia/reperfusion injury?
Selective inhibition of PI3K gamma/delta with TG100-115 limits infarct size and preserves myocardial function in animal models of ischemia/reperfusion injury, even when administered up to 3 hours post-reperfusion.
Doukas et al. (2006) studied this question.
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