What question did this study set out to answer?

To evaluate the comparative effectiveness of first-line benzodiazepines for terminating seizures in adults with convulsive status epilepticus.

First‐Line Benzodiazepine Treatment for Convulsive Status Epilepticus in Adults: A Systematic Review and Meta‐Analysis

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A systematic review compares the effectiveness of benzodiazepines for seizure termination in adults with CSE, suggesting optimal treatment options.

To evaluate the comparative effectiveness of first-line benzodiazepines for terminating seizures in adults with convulsive status epilepticus.
Conducted a systematic review and meta-analysis of randomized controlled trials.
Included studies involving adult patients with convulsive status epilepticus receiving benzodiazepines.
Performed a comprehensive search in MEDLINE and other databases.
Intravenous lorazepam showed a higher seizure termination rate compared to intravenous diazepam (RR 1.24).
Intramuscular midazolam was associated with higher seizure termination rates than intravenous lorazepam in prehospital settings (RR 1.16).
No increase in adverse outcomes was noted with intravenous lorazepam compared to diazepam.

Togo et al. (2026) studied this question.

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A systematic review compares the effectiveness of benzodiazepines for seizure termination in adults with CSE, suggesting optimal treatment options.