Physiologically relevant ethanol exposure alters neurexin expression in human neuroblastoma cells, suggesting implications for synapse stability.
Physiologically relevant ethanol exposure alters NRXN expression in an isoform-, splice site-, and differentiation-dependent manner, prominently affecting NRXN3 and the SS4 site. These coordinated transcriptional and proteomic changes suggest that ethanol perturbs NRXN3β-NLGN2 interactions and inhibitory synapse stability, revealing a molecular pathway where alcohol may compromise cortical network excitatory-inhibitory balance.
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Lowe et al. (2026) studied this question.
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