Skin-deep connections: likelihood of skin-scarring history in patients with stricturing/penetrating Crohn disease compared with patients with nonstricturing/nonpenetrating disease and non–inflammatory bowel disease controls

Mustafa Mohamedrashed; Saiumaeswar Yogakanthi; Ayushi Chauhan; Sarah Lucas; Aaron J. Robinson; Mayur Garg

doi:10.1093/ibd/izag058

March 24, 2026Inflammatory Bowel Diseases

Skin-deep connections: likelihood of skin-scarring history in patients with stricturing/penetrating Crohn disease compared with patients with nonstricturing/nonpenetrating disease and non–inflammatory bowel disease controls

View at Publisher

Ask AI

Bookmark

Share

Key Points

This study aims to explore the connection between skin scarring and different forms of Crohn disease.
Conducted a cross-sectional proof-of-concept analysis.
Compared patients with stricturing/penetrating Crohn disease to those with nonstricturing disease and non-IBD controls.
Assessed the frequency of hypertrophic and keloid scars.
Patients with stricturing/penetrating Crohn disease exhibited significantly more hypertrophic and keloid scars.
Potential shared mechanisms of fibrosis were suggested between skin and intestinal conditions.
Findings indicate a need for further research in larger, longitudinal studies.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Cross-sectional study shows increased skin scarring in stricturing Crohn disease, suggesting fibrotic links.

Abstract

Summary Patients with stricturing/penetrating Crohn disease had significantly more hypertrophic/keloid scars than those with nonstricturing disease in this cross-sectional proof-of-concept study, suggesting potential shared fibrotic mechanisms between cutaneous and intestinal fibrosis. If corroborated in larger and more longitudinal cohorts, overcoming potential confounders such as postsurgical scars, this novel association may help identify patients at risk and facilitate development of targeted antifibrotic therapies.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Mohamedrashed et al. (2026) studied this question.

synapsesocial.com/papers/69df2c88e4eeef8a2a6b1c24 https://doi.org/10.1093/ibd/izag058

View at Publisher

Ask AI

Bookmark

Share

Skin-deep connections: likelihood of skin-scarring history in patients with stricturing/penetrating Crohn disease compared with patients with nonstricturing/nonpenetrating disease and non–inflammatory bowel disease controls

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Skin-deep connections: likelihood of skin-scarring history in patients with stricturing/penetrating Crohn disease compared with patients with nonstricturing/nonpenetrating disease and non–inflammatory bowel disease controls

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading