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Demonstrates biphasic complement activation in patients undergoing cardiopulmonary bypass, indicating links between postoperative CRP levels and arrhythmias.
Cardiac surgery with CPB causes a biphasic complement activation. The first phase occurs during CPB and results from the interaction of blood with the extracorporeal circuit. The second phase, which occurs during the first 5 days after surgery, involves CRP, is related to baseline CRP levels, and is associated with clinical symptoms such as arrhythmia.
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Bruins et al. (1997) studied this question.
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