What question did this study set out to answer?

To investigate the role of complement activation during total cardiopulmonary bypass and its impact on inflammatory responses.

February 26, 1981New England Journal of Medicine

Complement Activation during Cardiopulmonary Bypass

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Authors

DCDennis E. ChenowethHuman Genome Sciences (United States)SCSteven W. CooperEastern Kentucky University THTony E. HugliOklahoma State University

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Implication

Randomized trial observes complement activation affecting inflammatory responses during cardiopulmonary bypass, suggesting potential pathogenesis for post-pump syndromes.

Key Points

To investigate the role of complement activation during total cardiopulmonary bypass and its impact on inflammatory responses.
Observed complement levels in 15 adults undergoing cardiopulmonary bypass.
Measured plasma levels of C3a and C5a at different time points during the procedure.
Evaluated neutrophil responses including neutrophilia and transpulmonary neutropenia.
C3a levels increased significantly at the beginning (P < 0.0001) and were over five times higher at the end of the procedure.
Neutrophilia was significant during bypass (P = 0.03), and transpulmonary neutropenia occurred upon reestablishment of circulation (P = 0.0002).
Blood incubation with nylon-mesh liners and vigorous oxygenation promoted complement conversion.

Cite This Study

Chenoweth et al. (1981) studied this question.

synapsesocial.com/papers/6a0fa789d8c5cf602efcfd5d https://doi.org/10.1056/nejm198102263040901

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Implication

Randomized trial observes complement activation affecting inflammatory responses during cardiopulmonary bypass, suggesting potential pathogenesis for post-pump syndromes.

Complement Activation during Cardiopulmonary Bypass

Discussion

Member takes

Implication

Key Points

Cite This Study

Complement Activation during Cardiopulmonary Bypass

Discussion

Member takes

Implication

Key Points

Cite This Study

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