Why the study?
Do ACE inhibitors provide better renoprotective effects compared to ARBs and other antihypertensive drugs in patients with diabetes?
Do ACE inhibitors provide better renoprotective effects compared to ARBs and other antihypertensive drugs in patients with diabetes?
The findings support the use of ACE inhibitors as the first-line antihypertensive agent in patients with diabetes, potentially combined with calcium channel blockers if needed.
Supports ACE inhibitors as first-line antihypertensives for renoprotection in diabetes; confirms superiority over ARBs in Level 1 evidence.
Our analyses show the renoprotective effects and superiority of using ACE inhibitors in patients with diabetes, and available evidence is not able to show a better effect for ARBs compared with ACE inhibitors. Considering the cost of drugs, our findings support the use of ACE inhibitors as the first line antihypertensive agent in patients with diabetes. Calcium channel blockers might be the preferred treatment in combination with ACE inhibitors if adequate blood pressure control cannot be achieved by ACE inhibitors alone.
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Wu et al. (2013) studied this question.