Prognostic Importance of Pathophysiologic Markers in Patients With Heart Failure and Preserved Ejection Fraction

Michael A. Burke; Daniel H. Katz; Lauren Beussink‐Nelson; Senthil Selvaraj; Deepak K. Gupta; Justin M. Fox; Sudarsana Chakrabarti; Andrew J. Sauer; Jonathan D. Rich; Benjamin H. Freed; Sanjiv J. Shah

doi:10.1161/circheartfailure.113.000854

December 24, 2013Circulation Heart FailureOpen Access

Prognostic Importance of Pathophysiologic Markers in Patients With Heart Failure and Preserved Ejection Fraction

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Why the study?

Do reduced LV compliance and RV remodeling predict adverse outcomes in patients with HFpEF?

Key Points

To determine the key pathophysiologic predictors of adverse clinical outcomes in individuals with heart failure and preserved ejection fraction (HFpEF).
Evaluated pathophysiologic markers of cardiac structure and function in patients diagnosed with HFpEF.
Assessed the association between specific ventricular mechanics, remodeling indices, and subsequent adverse clinical outcomes.
Reduced left ventricular (LV) compliance was identified as one of the strongest pathophysiologic predictors of adverse outcomes.
Right ventricular (RV) remodeling independently served as a leading predictor of unfavorable patient prognosis.

Structured PICO

Do reduced LV compliance and RV remodeling predict adverse outcomes in patients with HFpEF?

P

Population

Patients with Heart Failure and Preserved Ejection Fraction (HFpEF)

I

Intervention

Presence of pathophysiologic markers (reduced LV compliance and RV remodeling)

O

Outcome

Adverse outcomes

Reduced LV compliance and RV remodeling serve as key prognostic markers for adverse outcomes in patients with HFpEF.

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Implication

May aid prognostic stratification in HFpEF; leaves open whether targeting these features improves outcomes.

Abstract

In patients with HFpEF, reduced LV compliance and RV remodeling are the strongest pathophysiologic predictors of adverse outcomes.

Discussion

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Cite This Study

Burke et al. (2013) studied this question.

synapsesocial.com/papers/69df405844b0122c4f7a1230 https://doi.org/10.1161/circheartfailure.113.000854

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Prognostic Importance of Pathophysiologic Markers in Patients With Heart Failure and Preserved Ejection Fraction

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Prognostic Importance of Pathophysiologic Markers in Patients With Heart Failure and Preserved Ejection Fraction

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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