Does perioperative anesthetic exposure and brain injury affect 12-month neurodevelopmental outcomes in neonates undergoing cardiac surgery?
Perioperative factors including volatile anesthetic exposure and brain injury are associated with worse 12-month neurodevelopmental outcomes in neonates after cardiac surgery.
After adjustment for multiple relevant covariates, we demonstrated an association between VAA exposure, brain injury, ICU length of stay, and lower neurodevelopmental outcome scores at 12 months of age. These findings support the need for further studies to identify potential modifiable factors in the perioperative care of neonates with CHD to improve neurodevelopmental outcomes.
Andropoulos et al. (Tue,) studied this question.