Why the study?
Why does VO2 max remain reduced after altitude acclimatization despite normalization of arterial O2 content in lowlanders?
Population
7 lowlanders
Comparison
Chronic hypoxia and acute hypoxia vs Sea level (SL) conditions
Design
Cohort
Follow-up
9-10 weeks at altitude, then 6 months later at sea level
Authors
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Reduced cardiac output may limit exercise capacity post-acclimatization; leaves open whether targeted interventions improve outcomes in chronic hypoxia.
Why does VO2 max remain reduced after altitude acclimatization despite normalization of arterial O2 content in lowlanders?
The failure to recover VO2 max after altitude acclimatization is driven by reduced cardiac output and its preferential redistribution to nonexercising tissues, rather than impaired oxygen transport to muscle mitochondria.
Calbet et al. (2003) studied this question.
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