Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2021RSC Medicinal ChemistryOpen Access

Nitrile-containing pharmaceuticals: target, mechanism of action, and their SAR studies

View Full Paper
Ask AI
Bookmark
Share

Authors

XWXi WangYWYuanxun WangXLXuemin Li

Discussion

Loading...

Member takes

Overview

Review reveals structural mechanisms of nitrile-containing drugs across clinical conditions, highlighting the nitrile group's utility in rational drug design and pharmacokinetic optimization.

Key Points

  • To review FDA-approved and clinical-stage nitrile-bearing therapeutics, evaluating their molecular targets, mechanisms of action, and structure-activity relationships across diverse medical indications.
  • Examined more than 30 FDA-approved nitrile-containing drugs and therapeutic candidates in clinical trials.
  • Categorized compounds by clinical usage while evaluating structure-activity relationship (SAR) data, pharmacokinetic profiles, and target-binding mechanisms.
  • More than 30 nitrile-containing pharmaceuticals have received FDA marketing approval to manage diverse clinical conditions.
  • Incorporating a nitrile group into chemical leads systematically enhances target binding affinity, optimizes pharmacokinetic properties, and reduces susceptibility to drug resistance.

Cite This Study

Wang et al. (2021) studied this question.

synapsesocial.com/papers/69dfb937de200760a8615373https://doi.org/10.1039/d1md00131k
View Full Paper
Ask AI
Bookmark
Share