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January 25, 2026Current Organic Chemistry

A Review on the Synthesis and Biological Evaluation of N-containing Heterocyclic Derivatives

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Authors

SCSampoorna ChanduAMAmbika ManupatiSGSreedhar Gundekari

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Overview

This review highlights the synthesis and biological properties of N-heterocyclic derivatives, suggesting future directions in drug development.

Key Points

  • The review aims to summarize recent advancements in the synthesis and biological evaluation of N-heterocyclic derivatives.
  • Reviewed recent synthetic strategies for N-heterocycles including metal-catalyzed and green chemistry approaches.
  • Analyzed the structure-activity relationships (SAR) of synthesized compounds.
  • Highlighted the biological evaluation of N-heterocycles against various diseases.
  • N-heterocycles showed promising anti-fungal, anti-inflammatory, and anticancer activities.
  • Certain derivatives exhibited significant cytotoxicity against human cancer cell lines.
  • Challenges such as poor solubility and metabolic instability were identified for some compounds.

Cite This Study

Chandu et al. (2026) studied this question.

synapsesocial.com/papers/6975b36bfeba4585c2d6ed8ahttps://doi.org/10.2174/0113852728379590251112105811
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