With the increase in antimicrobial resistance, new drug scaffolds with high efficacy, selectivity, and a safe profile have been developed. One such class of molecules is heterocyclic organic compounds, which exhibit unique structural characteristics, distinct pharmacokinetics, and strong biological interactions. In this group, thiazoles and their derivatives have attracted significant attention owing to their broad spectrum of antimicrobial activities, chemical diversity, and ease of derivatization. This review focuses on recent trends in the design, synthesis, and biological evaluation of thiazole derivatives as antimicrobial agents. More attention will be given to new derivatives of thiazoles that have shown promising antimicrobial activity against Gram-positive and negative bacteria, pathogenic fungi, and multidrug-resistant (MDR) strains. A discussion of structure-activity relationships (SARs) will highlight the key functional groups and structural motifs required for potent antimicrobial activity and selectivity. Additionally, the review will also address the potential of thiazole hybrid compounds with other scaffolds and their effects on different microbes.
Alhussaini et al. (Tue,) studied this question.
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