Synthesis and Antimicrobial Activity of Thiadiazole Derivatives: A Review

Synthesis of heterocyclic compounds has been interesting area from last some decades. Heterocyclic compounds play an important role in organic chemistry because of their biological activities. Heterocyclic compounds containing five-membered rings exhibit significant biological activities. Thiadiazole, a five-membered heterocyclic scaffold, contains nitrogen and sulfur heteroatoms and shows versatile biological activities; therefore, it is an important class of compounds for new drug development.1,3,4-thiadiazole and some of their derivatives show broad-spectrum pharmacological activity. Nowadays, resistance of bacteria and fungi towards modern medicine is a serious issue in healthcare. Therefore, the development of new antimicrobial agents is needed. This review highlights the main antimicrobial properties exhibited by 1,3,4-thiadiazole derivatives. Several 1,3,4-thiadiazole derivatives have demonstrated higher antimicrobial activity than the standard drugs, and the derivatives can be considered as lead compounds for drug synthesis.