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August 8, 2026Journal of Agricultural and Food Chemistry

Research Progresson Common Nitrogen-Containing Five-MemberedHeterocycles in Agricultural Fungicides over the Past Five Years

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Authors

CYChaoyan YuYZY.N. ZhangTLTongtong Liu

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Overview

Review summarizes advancements in nitrogen-containing heterocycles for fungicide development, highlighting design strategies and biological activity.

Key Points

  • This review aims to summarize the recent advancements in nitrogen-containing five-membered heterocycles for agricultural fungicide development.
  • Review of eight nitrogen-containing five-membered heterocycles including thiazoles, pyrazoles, and triazoles.
  • Discussion of emerging targets like GWT-1 and HDAC and advancements in pharmacophore-linked fragment virtual screening.
  • Evaluation of design strategies such as molecular hybridization, natural product exploration, and competitor-inspired innovation.
  • Pyrazole derivatives are the most extensively studied, accounting for 28.90% of research, while pyrrole derivatives make up only 1.40%.
  • Emerging targets and new screening strategies have expanded the target space for these compounds.
  • Ongoing challenges include incomplete understanding of structure-activity relationships and difficulties in synthesizing complex scaffolds.

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a76da7cf12abadc79814c80https://doi.org/10.1021/acs.jafc.6c07428
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Review on the Synthesis and Biological Evaluation of N-containing Heterocyclic Derivatives2026
  2. 2RECENT ADVANCES IN THE SYNTHESIS AND PHARMACOLOGICAL APPLICATIONS OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS2026
  3. 3Discovery of Nitrogen-Containing Heterocyclic Chain Amide Derivatives as Novel Fungicidal Agents via Multicomponent Strategies.2025 · 3 citations
  4. 4Pyrazolo[5,1-c][1,2,4]triazole: A Promising Emerging Biologically Active Scaffold in Medicinal Chemistry2025
  5. 5Synthetic Advances of Five‐Membered N‐Heterocycles via Amino‐Based Organocatalysis2026