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September 14, 2025

Discovery of Nitrogen-Containing Heterocyclic Chain Amide Derivatives as Novel Fungicidal Agents via Multicomponent Strategies.

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Authors

HWHexiang WangJRJunli RenFLFang Liu

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Overview

Multicomponent synthesis of new fungicidal agents reveals superior antifungal activity against multiple fungi, suggesting potential as SDH inhibitors.

Key Points

  • Most nitrogen-containing heterocyclic bisamide compounds showed antifungal effectiveness exceeding 80%.
  • Compound 4 demonstrated exceptional potency with an EC50 of 4.37 μg/mL against P. capsici, far surpassing boscalid.
  • Mechanistic studies, including DFT calculations, imply these compounds may act as potential SDH inhibitors.
  • No significant phytotoxic effects were noted on maize and wheat growth, supporting crop safety.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c6df6933b72be0b5e43c7dhttps://doi.org/10.1021/acs.jafc.5c06565
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