What question did this study set out to answer?

To evaluate the quality of experimental design, statistical analysis, and reporting standards in published biomedical research involving laboratory animals.

November 30, 2009PLoS ONEOpen Access

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

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Authors

CKCarol KilkennyIP Australia NPNick ParsonsUniversity of Warwick EKEd KadyszewskiPfizer (United States)

Discussion

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Implication

Systematic survey reveals widespread deficits in randomisation, blinding, and statistical reporting in animal research publications, highlighting the need for improved methodological standards.

Key Points

To evaluate the quality of experimental design, statistical analysis, and reporting standards in published biomedical research involving laboratory animals.
Searched Medline and EMBASE for published biomedical studies on live rats, mice, and non-human primates conducted at UK and US publicly funded research establishments.
Evaluated 271 publications (N=271) for stated hypotheses, animal characteristics (number, sex, age, weight), experimental design details, and statistical methods.
Only 59% of studies stated both the hypothesis or objective and the number and characteristics of the animals used.
Most publications failed to employ bias-reduction measures, with 87% omitting randomisation and 86% omitting blinding for animal selection and outcome assessment.
Among publications utilizing statistical analyses, only 70% described their specific analytical methods and presented results with a measure of error or variability.

Cite This Study

Kilkenny et al. (2009) studied this question.

synapsesocial.com/papers/69dff6136ea3fbd8f9e9c0ef https://doi.org/10.1371/journal.pone.0007824

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Implication

Systematic survey reveals widespread deficits in randomisation, blinding, and statistical reporting in animal research publications, highlighting the need for improved methodological standards.

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

Discussion

Member takes

Implication

Key Points

Cite This Study

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

Discussion

Member takes

Implication

Key Points

Cite This Study

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