Why the study?
Does chronic exercise reduce sympathetic nerve activity in rabbits with pacing-induced heart failure?
Does chronic exercise reduce sympathetic nerve activity in rabbits with pacing-induced heart failure?
Chronic exercise reduces sympathetic nerve activity and plasma angiotensin II in a rabbit model of pacing-induced heart failure.
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Exercise may attenuate sympathetic overdrive in experimental CHF; leaves open translation to human patients.
These data strongly suggest that EX reduces the sympathoexcitatory state in the setting of CHF. Enhanced arterial baroreflex sensitivity may contribute to this reduction. In addition, EX lowers plasma angiotensin II concentration in CHF. These data further suggest that the lowering of angiotensin II may contribute to the decrease in sympathetic nerve activity after EX in the CHF state.
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Liu et al. (2000) studied this question.
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