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Establish standardized criteria and correct for selection bias to systematically estimate and compare baseline mutation rates across diverse viral families.

July 21, 2010Journal of VirologyOpen Access

Viral Mutation Rates

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Authors

RSRafael SanjuánInstitute for Integrative Systems Biology MNMiguel NebotUniversitat de València NCNicola ChiricoUniversity of Insubria

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Implication

Systematic review uncovers broad variations in mutation rates across 23 DNA and RNA viruses, indicating RNA virus mutation rates negatively correlate with genome size.

Key Points

Establish standardized criteria and correct for selection bias to systematically estimate and compare baseline mutation rates across diverse viral families.
Critically analyzed data from over 40 published studies examining mutation frequencies across 23 distinct viruses.
Standardized rates to substitutions per nucleotide per cell infection (s/n/c) and per strand copying using a novel statistical correction for selection bias.
Mutation rates spanned 10⁻⁸ to 10⁻⁶ s/n/c for DNA viruses and 10⁻⁶ to 10⁻⁴ s/n/c for RNA viruses, demonstrating a negative correlation with genome size in RNA viruses.
Retroviruses exhibited mutation rates comparable to other RNA viruses rather than lower rates, and nucleotide substitutions occurred an average of four times more frequently than indels.
Rates per nucleotide per strand copying were consistently lower than per cell infection rates, particularly for double-stranded DNA viruses undergoing multiple copying rounds per cell.

Cite This Study

Sanjuán et al. (2010) studied this question.

synapsesocial.com/papers/69dff77ebdd89ea531860900 https://doi.org/10.1128/jvi.00694-10

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Implication

Systematic review uncovers broad variations in mutation rates across 23 DNA and RNA viruses, indicating RNA virus mutation rates negatively correlate with genome size.

Viral Mutation Rates

Discussion

Member takes

Implication

Key Points

Cite This Study

Viral Mutation Rates

Discussion

Member takes

Implication

Key Points

Cite This Study

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