Population
Spleen necrosis virus-based in vivo system (56,409 proviruses analyzed)
Design
Preclinical
Authors
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Equal retroviral mutation rates across replication stages in animal models; leaves open hypermutation roles in human viral evolution and pathogenesis.
Retroviral mutation rates during early and late stages of replication are equal or within twofold of each other, with evidence of A-to-G hypermutations suggesting a role for mammalian double-stranded RNA adenosine deaminase.
Kim et al. (1996) studied this question.
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