Why the study?
Does Grp94 overexpression reduce cardiomyocyte necrosis due to calcium overload and simulated ischemia in muscle cells and neonatal rat cardiomyocytes?
Does Grp94 overexpression reduce cardiomyocyte necrosis due to calcium overload and simulated ischemia in muscle cells and neonatal rat cardiomyocytes?
Overexpression of the stress-protein Grp94 protects cardiomyocytes from necrosis induced by calcium overload and simulated ischemia.
Authors
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Should not change practice; hypothesis-generating for Grp94 cardioprotection in ischemia models.
Vitadello et al. (2003) studied this question.