Why the study?
Does insulin infusion decrease large artery stiffness differently in uncomplicated type 1 diabetes mellitus compared to normal subjects?
Does insulin infusion decrease large artery stiffness differently in uncomplicated type 1 diabetes mellitus compared to normal subjects?
Insulin resistance in type 1 diabetes involves a defect in the ability of insulin to decrease central aortic pressure, potentially predisposing these patients to premature stiffening of large arteries.
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Hyperinsulinemia fails to reduce augmentation index in type 1 diabetes unlike controls; hypothesis-generating for vascular insulin resistance and requires prospective confirmation.
Westerbacka et al. (2000) studied this question.
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