Why the study?
Does chronic hyperglycemia impair endothelium-dependent vasodilatation and insulin sensitivity in patients with IDDM compared to normal subjects?
Population
18 patients with insulin-dependent diabetes mellitus (IDDM) and 9 normal subjects
Comparison
Brachial artery infusions of acetylcholine… vs Normal subjects (healthy controls)
Design
Case-control
Authors
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Impaired insulin sensitivity and endothelium-dependent vasodilation were associated with HbA1c in IDDM; hypothesis-generating for distinct mechanisms and interventional trials.
Does chronic hyperglycemia impair endothelium-dependent vasodilatation and insulin sensitivity in patients with IDDM compared to normal subjects?
Chronic hyperglycemia in IDDM is associated with impaired endothelium-dependent vasodilatation and a glucose extraction defect, suggesting distinct mechanisms for vascular dysfunction and insulin resistance.
̈kimattila et al. (1996) studied this question.
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