Key result
Acute hyperglycemia for 4 hours did not inhibit insulin's ability to increase skeletal muscle microvascular perfusion but provoked a slight increase in aortic stiffness.
Why the study?
Clinical data were lacking on how acutely the vasculature responds to hyperglycemia, and whether dynamic effects of acute hyperglycemia influence insulin-mediated micro- and macrovascular function.
Does acute hyperglycemia inhibit insulin's effects on microvascular perfusion in healthy young adults?
Population
Healthy young adults
Comparison
Insulin infusion during hyperglycemia vs euglycemia
Design
Randomized crossover trial
Authors
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Acute hyperglycemia does not blunt insulin-mediated microvascular perfusion; leaves open whether this holds in diabetes or with prolonged exposure.
RCT
crossover
Does acute hyperglycemia inhibit insulin's effects on microvascular perfusion in healthy young adults?
Acute hyperglycemia for 4 hours does not inhibit insulin's ability to increase skeletal muscle microvascular perfusion in healthy humans, though it may provoke a slight increase in aortic stiffness.
Horton et al. (2020) conducted an RCT in Healthy. Hyperglycemic-hyperinsulinemia vs. Euglycemic-hyperinsulinemia was evaluated on Skeletal muscle microvascular blood volume and blood flow. Acute hyperglycemia for 4 hours did not inhibit insulin's ability to increase skeletal muscle microvascular perfusion but provoked a slight increase in aortic stiffness.
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