Why the study?
What are the single dose pharmacokinetics of pleconaril in neonates?
What are the single dose pharmacokinetics of pleconaril in neonates?
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Pharmacokinetic data support a pleconaril dosing regimen of 5.0 mg/kg every 8 to 12 hours for neonates with enteroviral infection.
The apparent age-dependent differences in the pharmacokinetics of pleconaril may in part be related to increased bioavailability of the drug in older children and adults than in neonates. Our data appear to support the use of a 5.0-mg/kg dose given every 8 to 12 h in future studies of pleconaril in neonatal patients with enteroviral infection.
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Kearns et al. (2000) studied this question.
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