May 1, 2000Arthritis & Rheumatism
Risk factors for the incidence and progression of radiographic knee osteoarthritis
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Discussion
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Implication
Review reveals distinct risk factors for knee osteoarthritis onset versus progression, suggesting progression stems from impaired intrinsic repair capacity.
Key Points
- To determine whether established risk factors differentially influence the incidence versus the radiographic progression of knee osteoarthritis.
- Synthesized observational evidence on common risk factors including obesity, previous joint injury, and physical activity in knee osteoarthritis.
- Evaluated structural disease markers by comparing osteophyte formation with joint space narrowing.
- Known risk factors such as obesity, knee injury, and physical activity drive disease incidence and osteophyte formation more than structural progression.
- Disease progression correlates with impaired intrinsic tissue repair capacity rather than the initial mechanical triggers.
Cite This Study
Cooper et al. (2000) studied this question.