April 1, 1997Arthritis & Rheumatism
Risk factors for incident radiographic knee osteoarthritis in the elderly. The framingham study
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Discussion
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Implication
Cohort study reveals female sex, higher body mass index, and physical activity drive incident knee osteoarthritis in older adults, highlighting preventive targets.
Key Points
- To identify longitudinal risk factors predicting the onset of incident radiographic knee osteoarthritis in an elderly population.
- Conducted a longitudinal cohort study among 598 Framingham Study participants without radiographic knee OA at baseline (mean age 70.5 years, 63.7% women).
- Evaluated weight-bearing knee radiographs obtained at baseline (1983–1985) and follow-up (1992–1993) to detect incident OA, defined as Kellgren and Lawrence grade ≥2.
- Applied univariate and multivariate regression equations to examine baseline and interim risk factors associated with incident knee OA.
- Incident knee OA developed in 93 of 598 participants (15.6%), with women exhibiting higher risk than men after multivariable adjustment (OR = 1.8, 95% CI 1.1–3.1).
- Risk increased with baseline body mass index (OR = 1.6 per 5-unit increase, 95% CI 1.2–2.2), weight gain (OR = 1.4 per 10-lb increase, 95% CI 1.1–1.8, in women), and highest-quartile physical activity (OR = 3.3, 95% CI 1.4–7.5).
- Smoking ≥10 cigarettes daily was inversely associated with incident knee OA (OR = 0.4, 95% CI 0.2–0.8), whereas chondrocalcinosis and prior hand OA were not significantly associated.
Cite This Study
Felson et al. (1997) studied this question.