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The aim is to summarize evidence on predictors of growth response to rhGH therapy in children with IGHD.

April 16, 2026ChildrenOpen Access

Predictors of Response to Growth Hormone Therapy in Children with Idiopathic Growth Hormone Deficiency: A Narrative Review

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The aim is to summarize evidence on predictors of growth response to rhGH therapy in children with IGHD.
Reviewed studies on clinical, auxological, biochemical, and treatment-related factors influencing rhGH response.
Identified key predictors like early treatment initiation and growth markers.
Early treatment initiation, short stature at baseline, and prepubertal status predict better growth.
Biochemical markers like GH peak, IGF-1, and IGFBP-3 provide important supplementary information.
Modifiable factors, including GH dose and adherence to therapy, also impact outcomes.

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Narrative review examines factors influencing growth response to GH therapy in children with IGHD, suggesting individualized approaches.

Cammisa et al. (2026) studied this question.

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