This review highlights growth hormone efficacy variability in pediatric growth disorders, suggesting a shift towards personalized therapy.
Key Points
Individual responses to growth hormone therapy can vary significantly, impacting therapeutic outcomes and clinical decisions.
Key determinants of growth response include underlying diagnosis and growth hormone sensitivity, with conditions like severe deficiency showing better results.
Patient-specific factors, such as age at treatment initiation and height parameters, play a crucial role in shaping treatment effectiveness.
Emerging therapies aim to enhance adherence and target specific causes, representing a significant step towards tailored treatment in pediatric endocrinology.