What question did this study set out to answer?

The aim is to identify FDA-approved anticancer drugs that can inhibit the HPV-16 E6 protein, a key player in cervical cancer development.

April 16, 2026Scientific ReportsOpen Access

Integrated computational screening of FDA-approved anticancer drugs as novel HPV-16 E6 inhibitors in cervical cancer

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Authors

MAMahshid AhmadiGraduate University of Advanced Technology MYMehdi YoosefianGraduate University of Advanced Technology

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Implication

Integrated computational screening identifies FDA-approved drugs as potential HPV-16 E6 inhibitors, suggesting novel treatment strategies for cervical cancer.

Key Points

The aim is to identify FDA-approved anticancer drugs that can inhibit the HPV-16 E6 protein, a key player in cervical cancer development.
Integrated computational framework for drug repurposing
Screened 100 FDA-approved anticancer drugs using machine learning models
Gradient Boosting identified 21 potential E6 inhibitors
Molecular docking analyses prioritized five lead compounds based on binding affinities
Quantum chemical calculations analyzed electronic properties of compounds.
21 candidates identified as potential HPV-16 E6 inhibitors
Five compounds showed strong binding affinities between -8.13 to -9.24 kcal/mol
Gradient Boosting models achieved optimal performance metrics (MCC = 1.0, AUC = 1.0).

Cite This Study

Ahmadi et al. (2026) studied this question.

synapsesocial.com/papers/69e07d1d2f7e8953b7cbe32c https://doi.org/10.1038/s41598-026-42656-z

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Implication

Integrated computational screening identifies FDA-approved drugs as potential HPV-16 E6 inhibitors, suggesting novel treatment strategies for cervical cancer.

Integrated computational screening of FDA-approved anticancer drugs as novel HPV-16 E6 inhibitors in cervical cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Integrated computational screening of FDA-approved anticancer drugs as novel HPV-16 E6 inhibitors in cervical cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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