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Clinical evaluation of fecal sequencing and PCR detects Helicobacter pylori resistance in adults, suggesting a non-invasive diagnostic approach.
In the studied region, primary resistance to clarithromycin and quinolones in Helicobacter pylori exceeds 65% and rises sharply with age. Non-invasive fecal PCR or Sanger genotyping of 23S rRNA and gyrA mutations showed ≥85% agreement with invasive E-test results, enabling age-stratified, resistance-guided eradication therapy without endoscopy or culture.
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Xu et al. (2026) studied this question.
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