What question did this study set out to answer?

The aim is to compare fluorescence in situ hybridization with the epsilometer test for detecting H. pylori and its clarithromycin resistance in children.

December 1, 2002Alimentary Pharmacology & TherapeuticsOpen Access

Fluorescence in situ hybridization vs. epsilometer test for detection of clarithromycin‐susceptible and clarithromycin‐resistant Helicobacter pylori strains in gastric biopsies from children

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The aim is to compare fluorescence in situ hybridization with the epsilometer test for detecting H. pylori and its clarithromycin resistance in children.
Antral biopsies from 149 children were analyzed; 15 had prior anti-H. pylori therapy.
Fluorescence in situ hybridization and epsilometer tests were performed alongside culture and histological tests.
Susceptibility to clarithromycin was evaluated in two laboratories.
100% specificity was noted in 66 H. pylori-negative children.
Success rates were 90% for culture, 86% for epsilometer test, and 93% for fluorescence in situ hybridization in infected children.
Clarithromycin-resistant isolates were found in 22% of previously untreated children.

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Implication

Randomized trial compares detection methods for clarithromycin-resistant strains in children, indicating mixed infections are common.

Cite This Study

Feydt-Schmidt et al. (2002) studied this question.

synapsesocial.com/papers/6a703919ac440176ef28dfa7 https://doi.org/10.1046/j.1365-2036.2002.01382.x

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Fluorescence in situ hybridization vs. epsilometer test for detection of clarithromycin‐susceptible and clarithromycin‐resistant Helicobacter pylori strains in gastric biopsies from children

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Discussion

Implication

Cite This Study

Fluorescence in situ hybridization vs. epsilometer test for detection of clarithromycin‐susceptible and clarithromycin‐resistant Helicobacter pylori strains in gastric biopsies from children

Key Points

Discussion

Implication

Cite This Study

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