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April 16, 2026Journal of Herbmed Pharmacology0 citationsOpen Access

A comprehensive review on radioprotective potency and multifaceted biological activities of gallic acid

ZSZahra ShaghaghiHamedan University of Medical SciencesSZSaeedeh ZamaniLorestan University of Medical SciencesFFFarzad FathiHamedan University of Medical Sciences

Key Points

  • The aim is to evaluate the diverse biological activities of gallic acid, particularly its ability to protect against radiation and related damage.
  • Comprehensive literature review of research on gallic acid
  • Analysis of its effects on cancer cells and chemotherapeutic efficacy
  • Exploration of its protective role against radiation and toxicity
  • Review of GA's metabolism and biological distribution
  • Gallic acid demonstrated strong radioprotective properties against oxygen radicals
  • Showed potential in enhancing the efficacy of chemotherapy
  • Promoted cell death in cancer cells in a controlled manner
  • Provided protective benefits to vital organs like the liver, kidneys, and brain
  • Indicated benefits for nerve protection and vascular health.

Abstract

This review really digs into all the cool ways gallic acid (GA) can help with health, especially its strong powers in fighting off damage from oxygen radicals and stopping cancer from growing. We dive deep into how GA messes with different cancer cells, making them die off in a controlled way. The presentation also discusses how gallium enhances the efficacy of chemotherapeutic drugs, serving as a robust protective barrier against the adverse effects of chemotherapy. Moving on, we look at how GA helps protect the body from harm caused by radiation or other toxic substances, especially in important parts like the liver, kidneys, and brain. But GA’s not just about cancer; it’s also great at protecting the nerves, keeping blood vessels healthy, and even stopping diseases before they start. By the end, we get a full picture of how GA moves around the body, how it gets broken down, and all the ways it can protect the body, making it a really interesting natural substance for medical use. As no thorough study has yet explored this topic, this review seeks to comprehensively evaluate the most prominent research on the diverse biological activities of GA, including its radioprotective effects.

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Cite This Study

Shaghaghi et al. (2026) studied this question.

synapsesocial.com/papers/69e07e3b2f7e8953b7cbf473https://doi.org/10.34172/jhp.2026.52846
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gallic acid attenuates hypertension, cardiac remodeling, and fibrosis in mice with N G-nitro-L-arginine methyl ester-induced hypertension via regulation of histone deacetylase 1 or histone deacetylase 22017 · 69 citations
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  4. 4Chebulagic acid Chebulinic acid and Gallic acid, the active principles of Triphala, inhibit TNFα induced pro-angiogenic and pro-inflammatory activities in retinal capillary endothelial cells by inhibiting p38, ERK and NFkB phosphorylation2018 · 92 citations
  5. 5Effects of Gallic Acid on Memory Deficits and Electrophysiological Impairments Induced by Cerebral Ischemia/Reperfusion in Rats Following Exposure to Ambient Dust Storm2023 · 4 citations