Why the study?
Do elevated high-sensitivity troponin T levels predict mortality in dialysis patients without acute cardiac events?
Do elevated high-sensitivity troponin T levels predict mortality in dialysis patients without acute cardiac events?
Persistently elevated high-sensitivity troponin T levels double the mortality risk in dialysis patients, though large intraindividual variation suggests serial measurements may be needed for diagnostic utility.
May inform risk stratification in stable dialysis patients; hypothesis-generating and requires prospective validation before guiding practice.
A large proportion of prevalent dialysis patients without current established or ongoing cardiac events have elevated levels of high-sensitivity cTns. Mortality risk was doubled in patients with persistently high troponin T levels. The large intraindividual variation of cTns suggests that serial measurements and reference change levels may be used to improve diagnostic utility. However, evidence-based recommendations require more data from large studies of dialysis patients with cardiac events.
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Snaedal et al. (2020) studied this question.
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