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April 17, 2026Discover MoleculesOpen Access

1, 2, 4-Triazole-benzoyl aza glycinamide hybrids: design, synthesis, biological evaluation, and computational investigations on anticancer targets

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Authors

SBShaheen BegumAVAnitha Kumari VinjavarapuASArifa Begum Shaik

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Overview

Evaluation reveals anticancer properties of triazole-benzoyl hybrids in breast cancer, highlighting potential for new therapies.

Key Points

  • The aim is to design and evaluate 1,2,4-triazole-benzoyl azaglycinamide hybrids for anticancer and antibacterial activity.
  • Synthesis of twelve triazole-benzoyl azaglycinamide hybrids with diverse substituents.
  • Evaluation of anticancer activity using the MTT assay against MCF-7 cell line.
  • Screening for antibacterial activity against various bacteria.
  • Computational molecular docking studies to assess binding affinity to cathepsin B and EGFR.
  • Compound 3l exhibited notable cytotoxicity against MCF-7 with an IC50 of 27.32 µM, compared to cisplatin's 12.06 µM.
  • Molecular docking showed enhanced affinity of compounds 3f, 3c, and 3g for cathepsin B.
  • 3g and 3d demonstrated favorable binding with EGFR.
  • Compound 3l also displayed strong antibacterial activity against multiple tested organisms.

Cite This Study

Begum et al. (2026) studied this question.

synapsesocial.com/papers/69e1ce065cdc762e9d857292https://doi.org/10.1007/s44345-026-00051-1
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