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April 15, 2026Future Medicinal Chemistry

Unveiling the potential of zingerone-1,2,3-triazole derivatives as dual anticancer and COX-2 inhibitor: design, synthesis, and biological assessments

Mohammad Mahboob Alam Nawaf I. Alsenani Ahmed A. Elhenawy Rania A. Hussien Saif H. Althagafi Esam A. Alqurashi Serag Eldin I. Elbehairi Ali A. Shati Mohammad Y. Alfaifi Seham H. Bashir Syed Nazreen

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Key Points

The study aims to evaluate the anticancer and COX-2 inhibitory potential of zingerone-1,2,3-triazole derivatives.
Design and synthesis of zingerone triazole derivatives
Biological assessments to evaluate anticancer and COX-2 inhibitory activities
Assessment of pharmacokinetics and toxicity profiles
Zingerone hybrid demonstrated potent anticancer activity
Significant inhibition of COX-2 activity was observed
Favorable pharmacokinetics and low toxicity were noted

Implication

Research demonstrates potent anticancer and COX-2 inhibitory effects in zingerone derivatives, suggesting therapeutic promise.

Abstract

Zingerone hybrid (11) displayed potent anticancer and COX-2 inhibitory activity, with favorable pharmacokinetics and low toxicity.

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Cite This Study

Alam et al. (2026) studied this question.

synapsesocial.com/papers/69e1ce065cdc762e9d857303 https://doi.org/10.1080/17568919.2026.2658835

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