Unveiling the potential of zingerone-1,2,3-triazole derivatives as dual anticancer and COX-2 inhibitor: design, synthesis, and biological assessments

Key Points

• The study aims to evaluate the anticancer and COX-2 inhibitory potential of zingerone-1,2,3-triazole derivatives.
• Design and synthesis of zingerone triazole derivatives
• Biological assessments to evaluate anticancer and COX-2 inhibitory activities
• Assessment of pharmacokinetics and toxicity profiles
• Zingerone hybrid demonstrated potent anticancer activity
• Significant inhibition of COX-2 activity was observed
• Favorable pharmacokinetics and low toxicity were noted