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April 15, 2026Translational Vision Science & TechnologyOpen Access

Parameter-Dependent Effects of Rose Bengal Photodynamic Antimicrobial Therapy on MRSA Inhibition and Corneal Cytokine Expression

Alejandro Arboleda Heather Durkee Mariela C Aguilar Jorge Maestre-Mesa Felipe Echeverri Tribin Brandon Chou Nidhi Relhan Nicholas Nolan Cornelis Rowaan Alex González Karam Alawa Harry W. Flynn Guillermo Amescua J. M. M. Parel D. C. Miller

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Key Points

The research investigates the effects of rose bengal photodynamic antimicrobial therapy (PDAT) on MRSA inhibition and cytokine expression in the cornea.
Examined the inhibitory effects of rose bengal PDAT on MRSA
Assessed cytokine expression in corneal tissues
Evaluated different parameters influencing therapeutic outcomes
Rose bengal PDAT significantly suppressed MRSA growth
Treatment altered inflammatory cytokine levels in corneal tissues

Implication

Innovative therapy reduces MRSA and alters cytokine response in corneal infections, indicating potential benefits for treatment.

Abstract

Rose bengal PDAT effectively suppresses MRSA and modulates inflammatory cytokines, supporting its use in microbial keratitis.

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Cite This Study

Arboleda et al. (2026) studied this question.

synapsesocial.com/papers/69e1cecc5cdc762e9d857c5f https://doi.org/10.1167/tvst.15.4.14

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Rose Bengal diacetate-mediated antimicrobial photodynamic inactivation: potentiation by potassium iodide and acceleration of wound healing in MRSA-infected diabetic mice2024 · 16 citations
2Rose Bengal Photodynamic Therapy (RB-PDT) Modulates the Inflammatory Response in LPS-Stimulated Human Corneal Fibroblasts By Influencing NF-κB and p38 MAPK Signaling Pathways2024 · 2 citations
3Rose Bengal Electromagnetic Activation With Green Light for Infection ReductionRCT · 2026
4Clinical Outcomes of Rose Bengal Photodynamic Therapy for Severe Infectious Keratitis2025 · 5 citations
5In Vitro Evaluation of Photoactivated Rose Bengal for Growth Inhibition of Fungi Isolated From Keratitis2025 · 3 citations

More related papers

Rose bengal photodynamic antimicrobial therapy combined with amniotic membrane graft for the management of infectious keratitis in a patient with keratoprosthesis2025
Evaluation of Rose‐Bengal Photodynamic Antimicrobial Therapy for Refractory Infectious Keratitis in Dogs and Cats (22 Cases)2026
A double-masked, sham-controlled trial of rose bengal photodynamic therapy for the treatment of fungal and acanthamoeba keratitis: Rose Bengal Electromagnetic Activation with Green Light for Infection Reduction (REAGIR) study2024

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