Integration of a polygenic score into clinical risk prediction of atherosclerotic cardiovascular disease in familial hypercholesterolemia

Key Points

• To evaluate whether adding a polygenic score improves risk prediction of atherosclerotic cardiovascular disease in familial hypercholesterolemia.
• Assessment of ASCVD risk using the FH-Risk-Score.
• Addition of polygenic information through PRSCAD percentiles.
• Comparison of predictive accuracy before and after integrating polygenic scores.
• No significant enhancement in ASCVD risk prediction with the addition of polygenic scores.
• Further research with larger populations and more incident cases is needed.