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April 17, 2026Physiological ReportsOpen Access

Sex‐dependent effects of environmental enrichment on mood‐related behaviors, central and peripheral BDNF , and adrenal catecholamine enzymes in mice

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Authors

MHM. F. HerselmanSLS. Y. LuoLLLong Lin

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Overview

Investigation reveals sex differences in mood behaviors and BDNF levels in mice exposed to environmental enrichment, suggesting implications for research.

Key Points

  • This study aims to investigate the influence of environmental enrichment on mood-related behaviors and BDNF levels in male and female mice.
  • Mice were housed in environmentally enriched conditions.
  • Behavioral assessments of anxiety-like behaviors were conducted.
  • Levels of BDNF in the brain and peripheral tissues were measured.
  • The expression of adrenal catecholamine biosynthetic enzymes was analyzed.
  • Female mice showed increased anxiety-like behaviors with environmental enrichment.
  • Male mice exhibited elevated hippocampal BDNF levels without increased anxiety-like behavior.
  • Adrenal catecholamine enzyme levels increased in females but remained unchanged in males.

Cite This Study

Herselman et al. (2026) studied this question.

synapsesocial.com/papers/69e1cf625cdc762e9d8583ebhttps://doi.org/10.14814/phy2.70870
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology2026
  2. 2Effect of six weeks of environmental enrichment on oxidative metabolism and hypothalamic mitochondrial markers of adult male mice2026
  3. 3Adolescent envy-like social comparison stress induces HPA axis hypoactivity and anxiety in female mice: implications for somatic symptom disorder2026
  4. 4Short- and Long-Term Effects of Subchronic Stress Exposure in Male and Female Brain-Derived Neurotrophic Factor Knock-In Val66Met Mice2024 · 4 citations
  5. 5Sex-Specific Reversal of Stress-Induced Depressogenic Behaviors by Inhibition of HMGB1, TLR4, and NF-κB Signaling2026