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June 17, 2026NeuropsychopharmacologyOpen Access

Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology

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Authors

SBSavannah BrannanBRB. D. Richardson

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Overview

Randomized trial shows altered cognitive and affective behaviors in mice exposed to early life stress, implying a link to norepinephrine activity.

Key Points

  • This research aims to investigate how early life stress impacts cognitive and affective behaviors, with a focus on sex differences in noradrenergic physiology.
  • Applied two-phase early life variable stress (ELVS) to C57BL/6J mice.
  • Assessed behavioral changes such as exploration and sucrose preference, alongside LC neuron physiology.
  • Examined sex-specific physiological responses in noradrenergic pathways after ELVS exposure.
  • Female mice showed increased novel environment exploration (p<0.05) and reduced sucrose preference (p<0.01).
  • Modest deficits in Y-maze performance were observed in both sexes (no specific p-value provided).
  • Reboxetine administration corrected behavioral changes linked to ELVS, indicating the involvement of norepinephrine pathways.

Cite This Study

Brannan et al. (2026) studied this question.

synapsesocial.com/papers/6a323e06d50b63ecad2076cbhttps://doi.org/10.1038/s41386-026-02463-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early life stress induced sex-specific changes in behavior is paralleled by altered locus coeruleus physiology in BALB/cJ mice2024
  2. 2Maternal separation disrupts noradrenergic control of adult coping behaviors2025
  3. 3Sex-specific fear acquisition following early life stress is linked to amygdala glutamate metabolism2024 · 3 citations
  4. 4Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model2018 · 251 citations
  5. 5Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo2026 · 5 citations