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The study aims to profile metabolites and assess the antioxidant and antibacterial potential of Achillea clypeolata extracts.

April 17, 2026FoodsOpen Access

UHPLC-ESI-Orbitrap-MS/MS Untargeted Metabolomic Profiling and In Vitro Antioxidant and Antibacterial Activity of Different Achillea clypeolata Sibth. & Sm. Extracts

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This research reveals antioxidant and antibacterial activities in Achillea clypeolata extracts, highlighting potential medicinal uses.

The study aims to profile metabolites and assess the antioxidant and antibacterial potential of Achillea clypeolata extracts.
Conducted untargeted metabolomic profiling using UHPLC-ESI-Orbitrap-MS/MS.
Extracted compounds using 70% methanol, 70% ethanol, and water.
Performed in vitro antioxidant and antibacterial activity assays.
Identified 62 compounds, mostly flavonoids and organic acids.
Methanol extract exhibited the highest antioxidant potential.
Methanol extract had the lowest minimum inhibitory concentration against Gram-positive bacteria.
Ethanol extract showed better inhibition of Gram-negative bacteria growth.
Ethanol extract had the lowest minimum bactericidal concentration against S. aureus.

Choneva et al. (2026) studied this question.

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