What question did this study set out to answer?

This study aims to evaluate the phytochemical composition and biological activities of the endemic Achillea clypeolata compared to the well-known Achillea millefolium.

May 22, 2026PharmaceuticsOpen Access

Unveiling the Bioactive Potential of the Aerial Parts of Balkan Achillea clypeolata: Comparison with Officinal Achillea millefolium

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This study aims to evaluate the phytochemical composition and biological activities of the endemic Achillea clypeolata compared to the well-known Achillea millefolium.
Evaluated chemical composition using UHPLC-MS/MS, HPLC, and FT-IR.
Assessed anti-inflammatory potential via erythrocyte membrane stabilization assay; tested enzyme-inhibitory activity against several enzymes.
Conducted DPPH, ABTS, and DCFDA assays for antioxidant activity and used broth microdilution method for antimicrobial testing.
Extracts showed significant anti-inflammatory activity, with A. millefolium providing greater protection against heat-induced hemolysis.
Both extracts inhibited collagenase, elastase, hyaluronidase, and tyrosinase in a concentration-dependent manner and exhibited strong antioxidant activity in ABTS and DPPH assays.
Moderate cytotoxicity was noted for A. clypeolata, showing stronger effects at certain concentrations, while both species displayed broad-spectrum antimicrobial activity, especially against Gram-positive bacteria.

Authors

KŠKatarina ŠavikinInstitute for Plant Protection and Environment AJAleksandra JovanovićUniversity of Belgrade APAndrea PirkovićUniversity of Belgrade

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Implication

Randomized trial compares biological potential of Achillea clypeolata with Achillea millefolium, highlighting its medicinal properties.

Cite This Study

Šavikin et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff42fd674f7c03778d4d2 https://doi.org/10.3390/pharmaceutics18050591

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Unveiling the Bioactive Potential of the Aerial Parts of Balkan Achillea clypeolata: Comparison with Officinal Achillea millefolium

Key Points

Discussion

Implication

Cite This Study

Unveiling the Bioactive Potential of the Aerial Parts of Balkan Achillea clypeolata: Comparison with Officinal Achillea millefolium

Key Points

Discussion

Implication

Cite This Study

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