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This review aims to evaluate the antileishmanial activity of various medicinal plants through in vitro studies.

Antileishmanial potential of medicinal plants: A global systematic and meta-analytic review of in vitro studies

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Systematic review reveals significant antileishmanial activity of medicinal plants, suggesting potential new treatments.

This review aims to evaluate the antileishmanial activity of various medicinal plants through in vitro studies.
Systematic retrieval of data from 2013 to 2025 across four databases.
Search included terms like 'plant extract', 'Leishmania', and 'herbal medicine'.
Inclusion of 29 studies with 271 in vitro experiments.
Half-maximal inhibitory concentration (D-IC₅₀) calculated for efficacy comparison.
Seventy-two plant species tested against Leishmania spp.
Significant heterogeneity among studies (I-square > 75%).
Linear regression analysis indicated significant activity in several plants and compounds.
Myrtus communis L., Peganum harmala, and Ferula macrecolea showed notable D-IC₅₀ values.
Terpinolene, plumericin, and ergosterol peroxide exhibited the strongest inhibitory effects.

Takzima et al. (2026) studied this question.

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