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April 18, 2026Journal of Bone and Mineral ResearchOpen Access

Asian ethnicity is associated with shorter anti-resorptive exposure prior to atypical femur fracture (AFF): a Transcontinental Atypical Femoral Fracture Consortium (TrAFFiC) cohort study

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Authors

LCLucy CollinsCSCat Shore-LorentiCCColin Chen

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Overview

Cohort study reveals Asian ethnicity linked to earlier atypical femur fracture onset, suggesting treatment adjustments.

Key Points

  • To explore the relationship between Asian ethnicity and the duration of anti-resorptive treatment before atypical femur fractures (AFFs).
  • Cohort study involving 166 patients with AFFs from the Transcontinental Atypical Femoral Fracture Consortium (TrAFFiC) registry.
  • Comparison of physical characteristics (height and weight) between Asian and non-Asian individuals with AFFs.
  • Assessment of prior trauma fracture history and response to teriparatide treatment.
  • Asian individuals had a lower average height (152.0 cm) compared to non-Asian peers (154.6 cm, p < 0.038).
  • Asian individuals weighed less (57.5 kg vs. 66.8 kg, p < 0.001) than their non-Asian counterparts.
  • Asian ethnicity was associated with a significantly higher likelihood of developing AFFs after ≤ 5 years of anti-resorptive treatment (OR 2.10, p = 0.034).
  • Southeast Asian ethnicity was linked to an even greater likelihood of earlier AFF development (OR 3.25, p = 0.002).

Cite This Study

Collins et al. (2026) studied this question.

synapsesocial.com/papers/69e3211640886becb65403c4https://doi.org/10.1093/jbmr/zjag070
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidemiology, Pathophysiology and Management of Atypical Femur Fractures: an Update2025
  2. 2Biochemical and Demographical Differences in Atypical vs. Typical Femoral Fractures: A 10‐Year Experience Across Two Centers2025
  3. 3Risk factors for atypical femur fractures with and without bisphosphonate treatment – A national nested case-control study2026
  4. 4Atypical Femoral Fractures in Adult Patients with Classical Osteogenesis Imperfecta2026
  5. 5P-028 ATYPICAL FEMUR FRACTURE AFTER DENOSUMAB TREATMENT: A CASE REPORT2026