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July 20, 2026Calcified Tissue InternationalOpen Access

Atypical Femoral Fractures in Adult Patients with Classical Osteogenesis Imperfecta

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Authors

MBMikolaj BartosikOWOskar WindelsFBFlorian Barvencik

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Overview

Randomized trial identifies atypical femoral fractures in adults with osteogenesis imperfecta, suggesting multifactorial origins.

Key Points

  • To investigate the prevalence and factors associated with atypical femoral fractures in adults with classical osteogenesis imperfecta.
  • Screened 138 adults with genetically confirmed osteogenesis imperfecta for atypical femoral fractures.
  • Identified 5 patients with atypical femoral fractures and compared them to a matched cohort of 23 individuals without fractures.
  • Analyzed demographics, biochemical markers, bone mineral density, and microarchitecture using HR-pQCT.
  • Atypical femoral fracture prevalence was found to be 3.6% among screened patients.
  • No significant demographic or treatment differences were observed between groups.
  • HR-pQCT indicated a trend of higher cortical thickness in patients with atypical femoral fractures.

Cite This Study

Bartosik et al. (2026) studied this question.

synapsesocial.com/papers/6a5dbab88bd453d3397abd6dhttps://doi.org/10.1007/s00223-026-01576-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidemiology, Pathophysiology and Management of Atypical Femur Fractures: an Update2025
  2. 2Biochemical and Demographical Differences in Atypical vs. Typical Femoral Fractures: A 10‐Year Experience Across Two Centers2025
  3. 3Rates and Pattern of Antifracture Drug Use in 6475 Adults and Children With Osteogenesis Imperfecta2025
  4. 4High Frequencies of Genetic Variants in Patients with Atypical Femoral Fractures2024 · 3 citations
  5. 5Risk factors for atypical femur fractures with and without bisphosphonate treatment – A national nested case-control study2026