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October 8, 2025Current Osteoporosis ReportsOpen Access

Epidemiology, Pathophysiology and Management of Atypical Femur Fractures: an Update

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Authors

LCLucy CollinsHNHanh H. NguyenFMFrances Milat

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Overview

Recent findings show anti-resorptive treatment increases atypical femur fracture risk, indicating new management strategies.

Key Points

  • Atypical femur fractures are linked to prolonged anti-resorptive treatment, causing increased risk and complications.
  • Emerging studies identify Asian ethnicity as a critical risk factor for atypical femur fractures in treated individuals.
  • Anti-resorptive therapy discontinuation should follow an atypical femur fracture, often requiring surgical intervention to address complications.
  • New research suggests teriparatide could assist healing in atypical femur fractures, particularly after surgical management.

Cite This Study

Collins et al. (2025) studied this question.

synapsesocial.com/papers/68e6679587ecc93a24d1754dhttps://doi.org/10.1007/s11914-025-00932-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Asian ethnicity is associated with shorter anti-resorptive exposure prior to atypical femur fracture (AFF): a Transcontinental Atypical Femoral Fracture Consortium (TrAFFiC) cohort study2026 · 1 citations
  2. 2Non-union after bisphosphonate-associated atypical femoral fractures: a review of the current literature2026
  3. 3Biochemical and Demographical Differences in Atypical vs. Typical Femoral Fractures: A 10‐Year Experience Across Two Centers2025
  4. 4Atypical Femoral Fractures in Adult Patients with Classical Osteogenesis Imperfecta2026
  5. 5Bisphosphonate‐Associated Atypical Femoral Fractures: A Description of Surgical Techniques in the Revision Fixation Setting With an Emphasis on Avoiding Varus Malalignment: A Two—Case Report2026